UF researchers link sepsis to poor long-term outcomes in ‘aged’ patients

Specifically, these patients can progress to a condition marked by chronic inflammation and muscle wasting, known as persistent inflammation, immunosuppression and catabolism syndrome, or PICS.

Welcome to the Sepsis and Critical Illness Research Center

The Sepsis and Critical Illness Research Center, the first of its kind in the nation, studies long-term outcomes in patients treated for sepsis in the surgical and trauma intensive care units at UF Health Shands Hospital, with the goal of developing clinical solutions for sepsis as well as illnesses that stem from it and their enduring, dismal effects.

Four main projects are being initiated in the center’s first five years of operation:

  • A project to study the course and outcomes of chronic, critical illness that follows sepsis in patients who have been in surgical and trauma ICUs.
  • A project to study how sepsis affects the kidneys and how these organs in turn may contribute to PICS and other forms of chronic illness.
  • A project to explore the possible role of immature immune system cells called myeloid-derived suppressor cells in the onset of PICS.
  • A project that focuses on one of the most debilitating effects of sepsis and PICS: muscle wasting.

Immunoregulation During Sepsis

Lyle Moldawer, PhD, associate director for the UF Sepsis and Critical Illness Research Center, presents "Immunoregulation During Sepsis" at the Society of Critical Care Medicine’s (SCCM) 44th Critical Care Congress held in January 2014.

 

 

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