dedicated to finding New solutions for sepsis

The UF Sepsis and Critical Illness Research Center (SCIRC) is the first of its kind in the nation and studies long-term outcomes in patients treated for sepsis in the UF Health Shands Hospital’s surgical and trauma intensive care units. With a focus on innovation, collaboration, and academic excellence, the center aims to address some of the most pressing challenges facing society. We are a diverse team of researchers and scholars who work tirelessly to push the boundaries of knowledge and drive positive change. Our goals is to develop clinical solutions for sepsis, as well as illnesses that stem from it and their enduring effects.

learn about our ongoing projects

See our newest publication:

 1) Adverse Long-Term Outcomes and an Immune Suppressed Endotype in Sepsis Patients with Reduced Interferon-γELISpot: A Multicenter, Prospective Observational Study.

Barrios EA, Mazer MB, McGonagill P, Bergmann CB, Goodman MD, Gould R, Rao M, Polcz V, Davis R, Del Toro D, Dirain M, Dram A, Hale L, Heidarian M, Kucaba TA, Lanz JP, McCray A, Meszaros S, Miles S, Nelson C, Rocha I, Silva EE, Ungaro R, Walton A, Xu J, Zeumer-Spataro L, Drewry A, Liang M, Bible LE, Loftus T, Turnbull I, Efron PA, Remy KE, Brakenridge S, Badovinac VP, Griffith TS, Moldawer LL, Hotchkiss RS, Caldwell CC. medRxiv. 2023 Sep 24:2023.09.13.23295360. doi: 10.1101/2023.09.13.23295360. Preprint. PMID: 37745385   (In Press, Journal of Clinical Investigation)

 2) Gut mycobiome dysbiosis after sepsis and trauma.

Park G, Munley JA, Kelly LS, Kannan KB, Mankowski RT, Sharma A, Upchurch G, Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Efron PA, Nagpal R. Gut mycobiome dysbiosis after sepsis and trauma. Crit Care. 2024 Jan 11;28(1):18. doi: 10.1186/s13054-023-04780-4. PMID: 38212826; PMCID: PMC10785534.