NARROWING THE GAP: PRECLINICAL TRAUMA WITH POSTINJURY SEPSIS MODEL WITH INCREASED CLINICAL RELEVANCE » Sepsis and Critical Illness Research Center » College of Medicine

SHOCK, Vol. 60, No. 2, pp. 272–279, 2023

🚨 New in Shock: Our team presents a novel, clinically relevant trauma + post-injury sepsis model that better reflects the human immune response following injury and infection.

📌 Narrowing the Gap: Preclinical Trauma with Postinjury Sepsis Model with Increased Clinical Relevance
📍 Jennifer Munley, Lauren Kelly, Gwendolyn Gillies, Erick Pons, Preston Coldwell, Kolenkode Kannan, Elizabeth Whitley, Letitia Bible, Philip Efron, and Alicia Mohr

🧬 This murine model incorporates blunt trauma, hemorrhagic shock, and intra-abdominal sepsis—offering a valuable tool to study the complex interplay of trauma and infection.

🔬 Designed to better mimic patient physiology, this model captures the persistent inflammation, immune dysfunction, and organ injury seen in trauma survivors.

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