SCIRC @ Shock 2025

SCIRC @ Shock 2025.

The Sepsis & Critical Illness Research Center (SCIRC) was proud to have a strong presence at the 2025 Conference on Shock in Boston, showcasing cutting-edge research across multiple abstracts and presentations. Our team’s contributions reflect SCIRC’s ongoing leadership in advancing the science of sepsis, inflammation, and critical care.

1. CHARACTERIZATION OF LUNG BACTERIAL AND FUNGAL MICROBIOME AFTER BURN AND INHALATION INJURY PATIENTS
   Authors: Robert Maile, Angel Charles
2. DAILY STRESS CHANGES THE PATHOBIOME FOLLOWING TRAUMATIC BRAIN INJURY IN RATS
   Authors: Bible, Letitia, Philip A. Efron
3. HUMAN HL-60 NEUTROPHILS CAN BE IMMUNOLOGICALLY REPROGRAMMED IN VITRO BY MICROBIAL PRODUCTS OF PREVOTELLA MELANINOGENICA, COMMONLY ISOLATED FROM THE LUNGS AFTER INHALATION INJUR
   Authors: Mariami Gogolishvili, Angel M. Charles, Ian R. Driscoll, Philip A. Efron, Shannon Wallet, Robert Maile
4. PLASMA EXTRACELLULAR VESICLES THAT ARISE AFTER WHOLE BODY IONIZING RADIATION INJURY CONTAIN MIRNA CARGO, DEPENDENT ON TIME AFTER INJURY, THAT CAN BE MECHANISTICALLY LINKED TO MACROPHAGE IMMUNE REPROGRAMMING
   Authors: Denise A. Hernandez¹, Madelyn P. Bucci², Maisie B. Mortlock¹, Heba I. El-Ahmad², Ian R. Driscoll¹, Shannon Wallet², Robert Maile¹
5. PLASMA-DERIVED EXTRACELLULAR VESICLES REPROGRAM IMMUNE SIGNALLING PATHWAYS IN MURINE MACROPHAGE POPULATIONS FOLLOWING WHOLE BODY IONIZING RADIATION INJURY
   Authors: Denise A. Hernandez1, Madelyn P. Bucci2, Maisie B. Mortlock1, Ian R. Driscoll1, Shannon Wallet2, Robert Maile1
6. PREVOTELLA MELANINOGENICA-DERIVED PRODUCTS ALTER THE INFLAMMATORY CYTOKINE RESPONSE OF HUMAN NK-92MI NATURAL KILLER (NK) CELLS IN VITRO
   Authors: Angel M. Charles, Mariami Gogolishvili, Ian R. Driscoll, Philip A. Efron, Shannon Wallet, Robert Maile
7. SINGLE-CELL TRANSCRIPTOME PROFILING REVEALS THE FUNCTION OF INNATE IMMUNE EFFECTOR CELLS IN MURINE NEONATAL SEPSIS
   Authors: Miguel Hernandez-Rios, Dayuan Wang, Valerie Polcz, Marvin Dirain, Ricardo Ungaro, Feifei Xiao, Philip Efron, Lyle Moldawer, Guoshuai Cai, Shawn D. Larson, Jaimar C. Rincon
8. SINGLE-CELL TRANSCRIPTOMICS REVEALS A DYSREGULATED PRO-INFLAMMATORY MYELOID CELL SIGNATURE IN MURINE NEONATAL POLYMICROBIAL SEPSIS
   Authors: Jaimar C. Rincon, Dayuan Wang, Miguel Hernandez-Rios, Christine Rodhouse, Marvin Dirain, Ricardo Ungaro, Feifei Xiao, Guoshuai Cai, Lyle Moldawer, Philip A. Efron, Shawn D. Larson
9. TRAJECTORY-SPECIFIC MATURATION OF NEONATAL MDSCS REVEALS UNIQUE IMMUNOLOGICAL FEATURES IN PRETERM INFANTS (Poster)
   Authors: Leandro Balzano-Nogueira, Miguel Hernandez-Rios, Valerie Polcz, Dayuan Wang, Ana P. Cabral, Marvin Dirain, Ricardo Ungaro, Christine Rodhouse, Guoshuai Cai, Lyle L. Moldawer, Philip A. Efron, Jaimar C. Rincon, Shawn D. Larson

10. UNIQUE AGE AND SEX MYELOID-DERIVED SUPPRESSOR CELL RESPONSES AFTER MURINE SEPSIS (Poster)
    Authors: Christine Rodhouse^1,2, Dayuan Wang^1,3, Hongru Tang^1,3, Miguel Hernandez-Rios^1,2, Kenneth L. Abbott^1,2, Jaimar Rincon^1,2, Robert Maile^1,2, Feifei Xiao^1,2, Lyle Moldawer^1,2, Guoshuai Cai^1,3, Philip A. Efron^1,2*
11. A NOVEL LENS INTO PRETERM NEONATAL PMN-MDSC INTERCELLULAR COMMUNICATION AT SINGLE-CELL LEVEL Authors: Miguel Hernández-Ríos¹, Leandro Balzano-Nogueira², Valerie Polcz¹, Dayuan Wang³, Ana P. Cabral¹, Marvin Dirain1, Ricardo Ungaro¹, Guoshuai Cai³, Lyle L. Moldawer¹, Philip A. Efron¹, Jaimar C. Rincón¹, Shawn D. Larson