The Sepsis and Critical Illness Research Center (SCIRC) proudly congratulates our collaborator, Orlando Laitano, Ph.D., on receiving an NIH R01 grant for his project, “Targeting Myofiber NAD(P)H Oxidases in Sepsis-Induced Myopathy” (1R01AR085126-01A1). 
Advancing Sepsis Research
Sepsis, a life-threatening condition that affects millions worldwide, often leaves survivors with long-term complications. Among the most devastating is sepsis-induced myopathy—severe muscle weakness and wasting that robs patients of their independence and quality of life. Dr. Laitano’s research aims to change this outcome by uncovering new strategies to restore muscle health in sepsis survivors.
A Novel Approach
Dr. Laitano’s lab has developed a groundbreaking mouse model that better mimics real patient conditions by combining sepsis with hindlimb suspension, modeling the effects of prolonged bedrest. This approach provides an innovative way to understand how sepsis disrupts muscle regeneration and why patients experience such profound weakness long after leaving the hospital.
The team is focusing on NADPH oxidases (NOX)—enzymes within skeletal muscle fibers and immune cells that appear to drive muscle dysfunction in sepsis. Early studies from Dr. Laitano’s lab have shown that blocking NOX activity protects against muscle weakness and wasting. His new project will test whether targeting NOX specifically in skeletal muscle fibers can preserve muscle function and improve recovery after sepsis.
Looking at Muscle Repair
Because the ability of muscles to regenerate is impaired in septic patients, the study will also examine the role of satellite cells (SCs)—specialized muscle stem cells essential for repair. By testing whether NOX inhibition improves SC function, Dr. Laitano’s work could reveal entirely new therapeutic pathways to restore strength in sepsis survivors.
Toward Better Patient Outcomes
This project has the potential to transform care for patients recovering from sepsis. By identifying new molecular targets to preserve muscle function and improve regeneration, Dr. Laitano’s research could pave the way for therapies that help survivors regain independence, improve quality of life, and ultimately enhance survival.
The SCIRC community is proud to celebrate this achievement and looks forward to continued collaboration with Dr. Laitano as we work together to improve outcomes for patients facing the long-term consequences of sepsis.
Congratulations, Dr. Laitano, on this well-deserved award!