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The Sepsis and Critical Illness Research Center, the first of its kind in the nation, studies long-term outcomes in patients treated for sepsis in the surgical and trauma intensive care units at UF Health Shands Hospital, with the goal of developing clinical solutions for sepsis as well as illnesses that stem from it and their enduring, dismal effects.  Administratively managed within the Department of Surgery, University of Florida College of Medicine, the sepsis center also encompasses the Laboratory of Inflammation Biology and Surgical Science.

Currently (summer, 2022), the sepsis center is focused on the following projects.

  • Studying long-term outcomes in survivors of critical illness, including severe trauma, sepsis and COVID19 infection.  These outcomes include not only hospital-free survival, but the long-term physical, function and cognitive effects of critical illness.
  • Understanding the underlying mechanisms that drive chronic critical illness in survivors of sepsis, trauma and COVID19 with a focus on ‘pathological activation’ of myeloid cell subsets.
  • Development of novel biomarkers that can be used not only to identify critically ill patients at risk of complicated clinical outcomes, but also individualized therapeutic interventions (personalized medicine).
  • Exploring the fundamental changes in bone marrow structure and function associated with critical illness and a dysregulated ’emergency myelopoiesis’ that occurs in survivors of trauma, sepsis and  COVID19
  • Better understanding how chronic critical illness and persistent inflammation drives cognitive decline in older adults and those with risk factors in dementia-associated diseases.
  • Investigating how chronic critical illness and immobility influence skeletal muscle wasting, the release of endogenous alarmins, and the persistent inflammation seen in older adults who survive sepsis, trauma and COVID19.