Publications Since 2020

1: Carmichael ED, Apple CG, Kannan KB, Gardener A, Anton S, Efron PA, Moldawer
LL, Moore FA, Brakenridge SC, Mohr AM. Chronic Critical Illness in Patients With
Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired
Functional Outcomes. Am Surg. 2022 May 20:31348221104252. doi:
10.1177/00031348221104252. Epub ahead of print. PMID: 35593749.

2: Efron PA, Darden DB, Li EC, Munley J, Kelly L, Fenner B, Nacionales DC,
Ungaro RF, Dirain ML, Rincon J, Mankowski RT, Leeuwenburgh C, Moore FA,
Brakenridge SC, Foster TC, Laitano O, Casadesus G, Moldawer LL, Mohr AM, Thomas
SURGICAL SEPSIS. J Trauma Acute Care Surg. 2022 Mar 24. doi:
10.1097/TA.0000000000003599. Epub ahead of print. PMID: 35324554.

3: Rani A, Barter J, Kumar A, Stortz JA, Hollen M, Nacionales D, Moldawer LL,
Efron PA, Foster TC. Influence of age and sex on microRNA response and recovery
in the hippocampus following sepsis. Aging (Albany NY). 2022 Jan
30;14(2):728-746. doi: 10.18632/aging.203868. Epub 2022 Jan 30. PMID: 35094981;
PMCID: PMC8833110.

4: Apple CG, Kelly LS, Kannan KB, Ungaro RF, Moore FA, Brakenridge SC, Moldawer
LL, Efron PA, Mohr AM. Ineffective Erythropoietin Response to Anemia in Sepsis.
Surg Infect (Larchmt). 2022 Mar;23(2):142-149. doi: 10.1089/sur.2021.152. Epub
2021 Dec 24. PMID: 34958257; PMCID: PMC8892986.

5: Loftus TJ, Ungaro R, Dirain M, Efron PA, Mazer MB, Remy KE, Hotchkiss RS,
Zhong L, Bacher R, Starostik P, Moldawer LL, Brakenridge SC. Overlapping but
Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and
Bacterial Sepsis: An Immunological Time Course Analysis. Front Immunol. 2021 Dec
9;12:792448. doi: 10.3389/fimmu.2021.792448. PMID: 34956225; PMCID: PMC8696010.

6: Brakenridge SC, Starostik P, Ghita G, Midic U, Darden D, Fenner B, Wacker J,
Efron PA, Liesenfeld O, Sweeney TE, Moldawer LL. A Transcriptomic Severity
Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis
Patients. Crit Care Explor. 2021 Oct 14;3(10):e0554. doi:
10.1097/CCE.0000000000000554. PMID: 34671746; PMCID: PMC8522866.

7: Darden DB, Brakenridge SC, Efron PA, Ghita GL, Fenner BP, Kelly LS, Mohr AM,
Moldawer LL, Moore FA. Biomarker Evidence of the Persistent Inflammation,
Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness
(CCI) After Surgical Sepsis. Ann Surg. 2021 Oct 1;274(4):664-673. doi:
10.1097/SLA.0000000000005067. PMID: 34506322; PMCID: PMC8592255.

8: Darden DB, Dong X, Brusko MA, Kelly L, Fenner B, Rincon JC, Dirain ML, Ungaro
R, Nacionales DC, Gauthier M, Kladde M, Brusko TM, Bihorac A, Moore FA, Loftus
T, Bacher R, Moldawer LL, Mohr AM, Efron PA. A Novel Single Cell RNA-seq
Analysis of Non-Myeloid Circulating Cells in Late Sepsis. Front Immunol. 2021
Aug 16;12:696536. doi: 10.3389/fimmu.2021.696536. PMID: 34484194; PMCID:

9: Darden DB, Ghita GL, Wang Z, Stortz JA, Lopez MC, Cox MC, Hawkins RB, Rincon
JC, Kelly LS, Fenner BP, Ozrazgat-Baslanti T, Leeuwenburgh C, Bihorac A, Loftus
TJ, Moore FA, Brakenridge SC, Baker HV, Bacher R, Mohr AM, Moldawer LL, Efron
PA. Chronic Critical Illness Elicits a Unique Circulating Leukocyte
Transcriptome in Sepsis Survivors. J Clin Med. 2021 Jul 21;10(15):3211. doi:
10.3390/jcm10153211. PMID: 34361995; PMCID: PMC8348105.

10: Darden DB, Mira JC, Lopez MC, Stortz JA, Fenner BP, Kelly LS, Nacionales DC,
Budharaju A, Loftus TJ, Baker HV, Moore FA, Brakenridge SC, Moldawer LL, Mohr
AM, Efron PA. Identification of unique microRNA expression patterns in bone
marrow hematopoietic stem and progenitor cells after hemorrhagic shock and
multiple injuries in young and old adult mice. J Trauma Acute Care Surg. 2021
Oct 1;91(4):692-699. doi: 10.1097/TA.0000000000003350. PMID: 34252063; PMCID:

11: Cox MC, Booth M, Ghita G, Wang Z, Gardner A, Hawkins RB, Darden DB,
Leeuwenburgh C, Moldawer LL, Moore FA, Efron PA, Anton S, Brakenridge SC. The
impact of sarcopenia and acute muscle mass loss on long-term outcomes in
critically ill patients with intra-abdominal sepsis. J Cachexia Sarcopenia
Muscle. 2021 Oct;12(5):1203-1213. doi: 10.1002/jcsm.12752. Epub 2021 Jun 30.
PMID: 34196134; PMCID: PMC8517344.

12: Rincon JC, Efron PA, Moldawer LL, Larson SD. Cecal Slurry Injection in
Neonatal and Adult Mice. Methods Mol Biol. 2021;2321:27-41. doi:
10.1007/978-1-0716-1488-4_4. PMID: 34048005; PMCID: PMC8482797.

13: Guirgis FW, Leeuwenburgh C, Moldawer L, Ghita G, Black LP, Henson M, DeVos
E, Holden D, Efron P, Reddy ST, Moore FA. Lipid and lipoprotein predictors of
functional outcomes and long-term mortality after surgical sepsis. Ann Intensive
Care. 2021 May 20;11(1):82. doi: 10.1186/s13613-021-00865-x. PMID: 34018068;
PMCID: PMC8136376.

14: Mankowski RT, Anton SD, Ghita GL, Brumback B, Darden DB, Bihorac A,
Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA. Older Adults
Demonstrate Biomarker Evidence of the Persistent Inflammation,
Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis. J Gerontol A
Biol Sci Med Sci. 2022 Jan 7;77(1):188-196. doi: 10.1093/gerona/glab080. PMID:
33721883; PMCID: PMC8751807.

15: Fenner BP, Darden DB, Kelly LS, Rincon J, Brakenridge SC, Larson SD, Moore
FA, Efron PA, Moldawer LL. Immunological Endotyping of Chronic Critical Illness
After Severe Sepsis. Front Med (Lausanne). 2021 Feb 15;7:616694. doi:
10.3389/fmed.2020.616694. PMID: 33659259; PMCID: PMC7917137.

16: Chen T, Delano MJ, Chen K, Sperry JL, Namas RA, Lamparello AJ, Deng M,
Conroy J, Moldawer LL, Efron PA, Loughran P, Seymour C, Angus DC, Vodovotz Y,
Chen W, Billiar TR. A road map from single-cell transcriptome to patient
classification for the immune response to trauma. JCI Insight. 2021 Jan
25;6(2):e145108. doi: 10.1172/jci.insight.145108. PMID: 33320841; PMCID:

17: Darden DB, Moore FA, Brakenridge SC, Navarro EB, Anton SD, Leeuwenburgh C,
Moldawer LL, Mohr AM, Efron PA, Mankowski RT. The Effect of Aging Physiology on
Critical Care. Crit Care Clin. 2021 Jan;37(1):135-150. doi:
10.1016/j.ccc.2020.08.006. Epub 2020 Oct 28. PMID: 33190766; PMCID: PMC8194285.

18: Ozrazgat-Baslanti T, Loftus TJ, Mohandas R, Wu Q, Brakenridge S, Brumback B,
Efron PA, Anton S, Moore FA, Moldawer LL, Segal MS, Bihorac A; Sepsis, Critical
Illness Research Center Investigators. Clinical Trajectories of Acute Kidney
Injury in Surgical Sepsis: A Prospective Observational Study. Ann Surg. 2022 Jun
1;275(6):1184-1193. doi: 10.1097/SLA.0000000000004360. Epub 2020 Nov 13. PMID:
33196489; PMCID: PMC8116352.

19: Moldawer LL, Darden DB, Efron PA. Reply to “Do Not Blame the Rodent for the
Failure of Developing Sepsis Therapies”. Shock. 2021 Jul 1;56(1):152-153. doi:
10.1097/SHK.0000000000001688. PMID: 33156239.

20: Efron PA, Darden DB, Wang Z, Nacionales DC, Lopez MC, Hawkins RB, Cox MC,
Rincon JC, Ungaro R, Dirain ML, Ghita GL, Chen T, Billiar TR, Delano MJ,
Leeuwenburgh C, Bihorac A, Brakenridge SC, Moore FA, Mohr AM, Tompkins RG,
Brumback BA, Baker HV, Upchurch GR, Moldawer LL. Transcriptomic responses from
improved murine sepsis models can better mimic human surgical sepsis. FASEB J.
2021 Feb;35(2):e21156. doi: 10.1096/fj.202002150R. Epub 2020 Nov 2. PMID:
33140449; PMCID: PMC7855423.

21: Bandyopadhyay S, Lysak N, Adhikari L, Velez LM, Sautina L, Mohandas R, Lopez
MC, Ungaro R, Peng YC, Kadri F, Efron P, Brakenridge S, Moldawer L, Moore F,
Baker HV, Segal MS, Ozrazgat-Baslanti T, Rashidi P, Bihorac A. Discovery and
Validation of Urinary Molecular Signature of Early Sepsis. Crit Care Explor.
2020 Sep 25;2(10):e0195. doi: 10.1097/CCE.0000000000000195. PMID: 33063018;
PMCID: PMC7523873.

22: Darden DB, Bacher R, Brusko MA, Knight P, Hawkins RB, Cox MC, Dirain ML,
Ungaro R, Nacionales DC, Rincon JC, Gauthier ML, Kladde M, Bihorac A, Brusko TM,
Moore FA, Brakenridge SC, Mohr AM, Moldawer LL, Efron PA. Single-Cell RNA-seq of
Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets
With Unique Transcriptional Responses: A Pilot Study. Shock. 2021 May
1;55(5):587-595. doi: 10.1097/SHK.0000000000001671. PMID: 33021571; PMCID:

23: Mankowski RT, Thomas RM, Darden DB, Gharaibeh RZ, Hawkins RB, Cox MC, Apple
C, Nacionales DC, Ungaro RF, Dirain ML, Moore FA, Leeuwenburgh C, Brakenridge
SC, Clanton TL, Laitano O, Moldawer LL, Mohr AM, Efron PA. Septic Stability? Gut
Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared
to Old Adult Mice. Shock. 2021 Apr 1;55(4):519-525. doi:
10.1097/SHK.0000000000001648. PMID: 32826817; PMCID: PMC7895866.

24: Cox MC, Brakenridge SC, Stortz JA, Hawkins RB, Darden DB, Ghita GL, Mohr AM,
Moldawer LL, Efron PA, Moore FA. Abdominal sepsis patients have a high incidence
of chronic critical illness with dismal long-term outcomes. Am J Surg. 2020
Dec;220(6):1467-1474. doi: 10.1016/j.amjsurg.2020.07.016. Epub 2020 Jul 25.
PMID: 32807383; PMCID: PMC7731616.

25: Rincon JC, Hawkins RB, Hollen M, Nacionales DC, Ungaro R, Efron PA, Moldawer
LL, Larson SD. Aluminum Adjuvant Improves Survival Via NLRP3 Inflammasome and
Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis. Shock. 2021
Feb 1;55(2):274-282. doi: 10.1097/SHK.0000000000001623. PMID: 32769820; PMCID:

26: Stortz JA, Cox MC, Hawkins RB, Ghita GL, Brumback BA, Mohr AM, Moldawer LL,
Efron PA, Brakenridge SC, Moore FA. Phenotypic heterogeneity by site of
infection in surgical sepsis: a prospective longitudinal study. Crit Care. 2020
May 7;24(1):203. doi: 10.1186/s13054-020-02917-3. PMID: 32381107; PMCID:

27: Mankowski RT, Anton SD, Ghita GL, Brumback B, Cox MC, Mohr AM, Leeuwenburgh
C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA. Older Sepsis Survivors
Suffer Persistent Disability Burden and Poor Long-Term Survival. J Am Geriatr
Soc. 2020 Sep;68(9):1962-1969. doi: 10.1111/jgs.16435. Epub 2020 Apr 15. PMID:
32294254; PMCID: PMC7654284.

28: Hawkins RB, Stortz JA, Holden DC, Wang Z, Raymond SL, Cox MC, Brakenridge
SC, Moore FA, Moldawer LL, Efron PA. Persistently increased cell-free DNA
concentrations only modestly contribute to outcome and host response in sepsis
survivors with chronic critical illness. Surgery. 2020 Mar;167(3):646-652. doi:
10.1016/j.surg.2019.11.018. Epub 2019 Dec 31. PMID: 31898953; PMCID: PMC7028489.

29: Hollen MK, Stortz JA, Darden D, Dirain ML, Nacionales DC, Hawkins RB, Cox
MC, Lopez MC, Rincon JC, Ungaro R, Wang Z, Wu Q, Brumback B, Gauthier ML, Kladde
M, Leeuwenburgh C, Segal M, Bihorac A, Brakenridge S, Moore FA, Baker HV, Mohr
AM, Moldawer LL, Efron PA. Myeloid-derived suppressor cell function and
epigenetic expression evolves over time after surgical sepsis. Crit Care. 2019
Nov 13;23(1):355. doi: 10.1186/s13054-019-2628-x. PMID: 31722736; PMCID:

30: Apple CG, Miller ES, Loftus TJ, Kannan KB, Thompson CW, Lopez MC, Baker HV,
Moldawer LL, Efron PA, Mohr AM. Effect of Beta-Blockade on the Expression of
Regulatory MicroRNA after Severe Trauma and Chronic Stress. J Am Coll Surg. 2020
Jan;230(1):121-129. doi: 10.1016/j.jamcollsurg.2019.09.011. Epub 2019 Oct 28.
PMID: 31672639; PMCID: PMC6934900.

31: Stortz JA, Hawkins RB, Holden DC, Raymond SL, Wang Z, Brakenridge SC,
Cuschieri J, Moore FA, Maier RV, Moldawer LL, Efron PA. Cell-free nuclear, but
not mitochondrial, DNA concentrations correlate with the early host inflammatory
response after severe trauma. Sci Rep. 2019 Sep 20;9(1):13648. doi:
10.1038/s41598-019-50044-z. PMID: 31541163; PMCID: PMC6754448