RM1 GM139690 Publications (2021–2025)
• Barrios EL, Balzano-Nogueira L, Polcz VE, Rodhouse C, Leary JR, Darden DB, Rincon JC, Dirain ML, Ungaro R, Nacionales DC, Larson SD, Sharma A, Upchurch G, Wallet SM, Brusko TM, Loftus TJ, Mohr AM, Maile R, Bacher R, Cai G, Kladde MP, Mathews CE, Moldawer LL, Brusko MA, Efron PA.
Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.
Front Immunol. 2024;15:1478471.
PubMed record for PMID: 39691721 • Free full-text article on PubMed Central
• Barrios EL, Leary JR, Darden DB, Rincon JC, Willis M, Polcz VE, Gillies GS, Munley JA, Dirain ML, Ungaro R, Nacionales DC, Gauthier ML, Larson SD, Morel L, Loftus TJ, Mohr AM, Maile R, Kladde MP, Mathews CE, Brusko MA, Brusko TM, Moldawer LL, Bacher R, Efron PA.
The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells.
Front Immunol. 2024;15:1355405.
PubMed record for PMID: 38720891 • Free full-text article on PubMed Central
• Barrios EL, Rincon JC, Willis M, Polcz VE, Leary JR, Darden DB, Balch JA, Larson SD, Loftus TJ, Mohr AM, Wallet S, Brusko MA, Balzano-Nogueira L, Cai G, Sharma A, Upchurch GR Jr, Kladde MP, Mathews CE, Maile R, Moldawer LL, Bacher R, Efron PA.
Transcriptomic differences in peripheral monocyte populations in septic patients based on outcome.
Shock. 2024;62(2):208-216.
PubMed record for PMID: 38713581 • Free full-text article on PubMed Central
• Barrios EL, Mazer MB, McGonagill PW, Bergmann CB, Goodman MD, Gould RW, Rao M, Polcz VE, Davis RJ, Del Toro DE, Dirain ML, Dram A, Hale LO, Heidarian M, Kim CY, Kucaba TA, Lanz JP, McCray AE, Meszaros S, Miles S, Nelson CR, Rocha IL, Silva EE, Ungaro RF, Walton AH, Xu J, Zeumer-Spataro L, Drewry AM, Liang M, Bible LE, Loftus TJ, Turnbull IR, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Moldawer LL, Hotchkiss RS, Caldwell CC.
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.
JCI Insight. 2024.
PubMed record for PMID: 38100268 • Free full-text article on PubMed Central
• Efron PA, Brakenridge SC, Mohr AM, Barrios EL, Polcz VE, Anton S, Ozrazgat-Baslanti T, Bihorac A, Guirgis F, Loftus TJ, Rosenthal M, Leeuwenburgh C, Mankowski R, Moldawer LL, Moore FA.
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
J Trauma Acute Care Surg. 2023;95(5):790-799.
PubMed record for PMID: 37561664 • Free full-text article on PubMed Central
• Polcz VE, Rincon JC, Hawkins RB, Barrios EL, Efron PA, Moldawer LL, Larson SD.
Trained immunity: A potential approach for improving host immunity in neonatal sepsis.
Shock. 2023;59(2):125-134.
PubMed record for PMID: 36383390 • Free full-text article on PubMed Central
• Polcz VE, Barrios EL, Chapin B, Price CC, Nagpal R, Chakrabarty P, Casadesus G, Foster T, Moldawer LL, Efron PA.
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.
Clin Sci (Lond). 2023;137(12):963-978.
PubMed record for PMID: 37337946 • Free full-text article on PubMed Central
• Price AD, Becker ER, Barrios EL, Mazer MB, McGonagill PW, Bergmann CB, Goodman MD, Gould RW, Rao M, Polcz VE, Kucaba TA, Walton AH, Miles S, Xu J, Liang M, Loftus TJ, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Moldawer LL, Hotchkiss RS, Caldwell CC.
Surviving septic patients endotyped with a functional assay demonstrate active immune responses.
Front Immunol. 2024;15:1418613.
PubMed record for PMID: 39469706 • Free full-text article on PubMed Central
• Rincon JC, Efron PA, Moldawer LL.
Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis.
J Leukoc Biol. 2022;112(6):1525-1534.
PubMed record for PMID: 36193662 • Free full-text article on PubMed Central
• Unsinger J, Osborne D, Walton AH, Han E, Sheets L, Mazer MB, Remy KE, Griffith TS, Rao M, Badovinac VP, Brakenridge SC, Turnbull I, Efron PA, Moldawer LL, Caldwell CC, Hotchkiss RS.
Temporal changes in innate and adaptive immunity during sepsis as determined by ELISpot.
Shock. 2024;62(2):255-264.
PubMed record for PMID: 38754032 • Free full-text article on PubMed Central
Publications — Efron
Note: RM1 publications above that include Efron are not repeated here.
[Efron-1] Charting the course for improved outcomes in chronic critical illness: therapeutic strategies for persistent inflammation, immunosuppression, and catabolism syndrome (PICS).
Polcz VE, Barrios EL, Larson SD, Efron PA, Rincon JC.
Br J Anaesth. 2024 Aug;133(2):260-263. doi:10.1016/j.bja.2024.05.005. Epub 2024 Jun 19. PMID: 38902117.
PubMed record for PMID: 38902117 — https://pubmed.ncbi.nlm.nih.gov/38902117/
[Efron-2] MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of ischemia/reperfusion injury after lung transplant.
Leroy V, Manual Kollareth DJ, Tu Z, Valisno JAC, Woolet-Stockton M, Saha B, Emtiazjoo AM, Rackauskas M, Moldawer LL, Efron PA, Cai G, Atkinson C, Upchurch GR Jr, Sharma AK.
JCI Insight. 2024 Aug 22;9(19):e179876. doi:10.1172/jci.insight.179876. PMID: 39172530.
PubMed record for PMID: 39172530 — https://pubmed.ncbi.nlm.nih.gov/39172530/
[Efron-3] Development and optimization of a diluted whole blood ELISpot assay to test immune function.
Ungaro RF, Xu J, Kucaba TA, Rao M, Bergmann CB, Brakenridge SC, Efron PA, Goodman MD, Gould RW, Hotchkiss RS, Liang M, Mazer MB, McGonagill PW, Moldawer LL, Remy KE, Turnbull IR, Caldwell CC, Badovinac VP, Griffith TS.
J Immunol Methods. 2024 Oct;533:113743. doi:10.1016/j.jim.2024.113743. Epub 2024 Aug 13. PMID: 39147231.
PubMed record for PMID: 39147231 — https://pubmed.ncbi.nlm.nih.gov/39147231/
[Efron-4] Persistence and sexual dimorphism of gut dysbiosis and pathobiome after sepsis and trauma.
Munley JA, Park G, Kelly LS, Kannan KB, Mankowski RT, Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Nagpal R, Efron PA.
Ann Surg. 2024 Sep 1;280(3):491-503. doi:10.1097/SLA.0000000000006385. Epub 2024 Jun 12. PMID: 38864230.
PubMed record for PMID: 38864230 — https://pubmed.ncbi.nlm.nih.gov/38864230/
[Efron-5] Antibiotic use in the surgical intensive care unit.
Laquian L, Efron PA.
Adv Surg. 2024 Sep;58(1):203-221. doi:10.1016/j.yasu.2024.04.012. Epub 2024 May 10. PMID: 39089778.
PubMed record for PMID: 39089778 — https://pubmed.ncbi.nlm.nih.gov/39089778/
[Efron-6] Community-engaged artificial intelligence research: A scoping review.
Loftus TJ, Balch JA, Abbott KL, Hu D, Ruppert MM, Shickel B, Ozrazgat-Baslanti T, Efron PA, Tighe PJ, Hogan WR, Rashidi P, Cardel MI, Upchurch GR Jr, Bihorac A.
PLOS Digit Health. 2024 Aug 23;3(8):e0000561. doi:10.1371/journal.pdig.0000561. PMID: 39178307.
PubMed record for PMID: 39178307 — https://pubmed.ncbi.nlm.nih.gov/39178307/
[Efron-7] Time to renal replacement therapy initiation in critically ill patients with acute kidney injury: A secondary analysis of the STARRT-AKI Trial.
Jeong R, Bagshaw SM, Ghamarian E, Harvey A, Joannidis M, Kirkham B, McAuley D, Ostermann M, Quenot JP, Young PJ, Wald R; STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Investigators.
Crit Care Med. 2025 Mar 3. doi:10.1097/CCM.0000000000006616. PMID: 40029115.
PubMed record for PMID: 40029115 — https://pubmed.ncbi.nlm.nih.gov/40029115/
[Efron-8] Current updates in precision and personalized medicine in sepsis and trauma.
Drury SK, Wallet SM, Maile R, Efron PA, Mohr AM, Bible L.
Surgery. 2024 Aug;176(2):541-543. doi:10.1016/j.surg.2024.03.048. PMID: 38760231.
PubMed record for PMID: 38760231 — https://pubmed.ncbi.nlm.nih.gov/38760231/
[Efron-9] Acute emergence of the intestinal pathobiome after postinjury pneumonia.
Munley JA, Kelly LS, Park G, Drury SK, Gillies GS, Coldwell PS, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM.
J Trauma Acute Care Surg. 2024 Jul 1;97(1):65-72. doi:10.1097/TA.0000000000004300. PMID: 38480488.
PubMed record for PMID: 38480488 — https://pubmed.ncbi.nlm.nih.gov/38480488/
[Efron-10] Antibiotic prophylaxis for elective pediatric laparoscopic cholecystectomies.
Rodhouse C, Raymond R, Neal D, Loftus TJ, Khan FA, Do AR, Taylor JA, Efron PA, Larson SD, Raymond SL.
J Pediatr Surg. 2025 Mar;60(3):162055. doi:10.1016/j.jpedsurg.2024.162055. PMID: 39549681.
PubMed record for PMID: 39549681 — https://pubmed.ncbi.nlm.nih.gov/39549681/
[Efron-11] An enteric bacterial infection triggers neuroinflammation and neurobehavioral impairment in 3xTg-AD transgenic mice.
Park G, Kadyan S, Hochuli N, Salazar G, Laitano O, Chakrabarty P, Efron PA, Zafar MA, Wilber A, Nagpal R.
J Infect Dis. 2024 Sep 10;230(Supplement_2):S95-S108. doi:10.1093/infdis/jiae165. PMID: 39255397.
PubMed record for PMID: 39255397 — https://pubmed.ncbi.nlm.nih.gov/39255397/
[Efron-12] Proteomic profiling of hindlimb skeletal muscle disuse in a murine model of sepsis.
Boeno FP, Roesch LFW, Efron PA, Laitano O.
Crit Care Explor. 2024 Aug 20;6(8):e1144. doi:10.1097/CCE.0000000000001144. PMID: 39162648.
PubMed record for PMID: 39162648 — https://pubmed.ncbi.nlm.nih.gov/39162648/
[Efron-13] A rare case of spontaneous hemoperitoneum in a bone marrow transplant recipient on VV-ECMO.
Donabedian P, Emtiazjoo AM, Rackauskas M, Efron P, Gries C, Burger M, Bible L, Reams V, Maybauer MO, Saha BK.
Am J Med Sci. 2025 Feb;369(2):296-300. doi:10.1016/j.amjms.2024.08.017. PMID: 39168408.
PubMed record for PMID: 39168408 — https://pubmed.ncbi.nlm.nih.gov/39168408/
[Efron-14] Postinjury pneumonia induces a unique blood microbiome signature.
Munley JA, Kelly LS, Park G, Pons EE, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM.
Shock. 2024 Dec 1;62(6):762-771. doi:10.1097/SHK.0000000000002428. PMID: 39178199.
PubMed record for PMID: 39178199 — https://pubmed.ncbi.nlm.nih.gov/39178199/
[Efron-15] Examining bile acids in pediatric sepsis — a step in the right direction.
Hernandez-Rios M, Rincon JC, Efron PA, Larson SD.
Pediatr Res. 2024 Nov 1. doi:10.1038/s41390-024-03673-8. PMID: 39482498.
PubMed record for PMID: 39482498 — https://pubmed.ncbi.nlm.nih.gov/39482498/
[Efron-16] Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients.
Polcz VE, Barrios EL, Cox MC, Rocha I, Liang M, Hawkins RB, Darden D, Ungaro R, Dirain M, Mankowski R, Mohr AM, Moore FA, Moldawer LL, Efron PA, Brakenridge SC, Loftus TJ.
Surgery. 2024 Nov;176(5):1516-1524. doi:10.1016/j.surg.2024.07.031. PMID: 39179433.
PubMed record for PMID: 39179433 — https://pubmed.ncbi.nlm.nih.gov/39179433/
[Efron-17] Exosomal microRNA following severe trauma: role in bone marrow dysfunction.
Munley JA, Willis ML, Gillies GS, Kannan KB, Polcz VE, Balch JA, Barrios EL, Wallet SM, Bible LE, Efron PA, Maile R, Mohr AM.
J Trauma Acute Care Surg. 2024 Apr 1;96(4):548-556. doi:10.1097/TA.0000000000004225. PMID: 38151766.
PubMed record for PMID: 38151766 — https://pubmed.ncbi.nlm.nih.gov/38151766/
[Efron-18] Incorporating patient values in large language model recommendations for surrogate and proxy decisions.
Nolan VJ, Balch JA, Baskaran NP, Shickel B, Efron PA, Upchurch GR Jr, Bihorac A, Tignanelli CJ, Moseley RE, Loftus TJ.
Crit Care Explor. 2024 Aug 12;6(8):e1131. doi:10.1097/CCE.0000000000001131. PMID: 39132980.
PubMed record for PMID: 39132980 — https://pubmed.ncbi.nlm.nih.gov/39132980/
[Efron-19] Association of sociodemographic factors with overtriage, undertriage, and value of care after major surgery.
Loftus TJ, Ruppert MM, Shickel B, Ozrazgat-Baslanti T, Balch JA, Abbott KL, Hu D, Javed A, Madbak F, Guirgis F, Skarupa D, Efron PA, Tighe PJ, Hogan WR, Rashidi P, Upchurch GR Jr, Bihorac A.
Ann Surg Open. 2024 May 1;5(2):e429. doi:10.1097/AS9.0000000000000429. PMID: 38911666.
PubMed record for PMID: 38911666 — https://pubmed.ncbi.nlm.nih.gov/38911666/
[Efron-20] Operating room supply cost and value of care after implementing a sustainable quality intervention.
Filiberto AC, Loftus TJ, Crippen CJ, Hu D, Balch JA, Efron PA, Sarosi GA Jr, Upchurch GR Jr.
J Am Coll Surg. 2024 Apr 1;238(4):404-413. doi:10.1097/XCS.0000000000000972. PMID: 38224109.
PubMed record for PMID: 38224109 — https://pubmed.ncbi.nlm.nih.gov/38224109/
[Efron-21] Association between preoperative anemia and cognitive function in a large cohort study of older patients undergoing elective surgery.
Howell K, Garvan C, Amini S, Kamyszek RW, Tighe P, Price CC, Spiess BD; PeCAN Program Study Group.
Anesth Analg. 2025 Jan 1;140(1):14-23. doi:10.1213/ANE.0000000000006998. PMID: 38985884.
PubMed record for PMID: 38985884 — https://pubmed.ncbi.nlm.nih.gov/38985884/
[Efron-22] A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia.
Kelly LS, Munley JA, Pons EE, Kannan KB, Whitley EM, Bible LE, Efron PA, Mohr AM.
Animal Model Exp Med. 2024 Jun;7(3):367-376. doi:10.1002/ame2.12447. PMID: 38860566.
PubMed record for PMID: 38860566 — https://pubmed.ncbi.nlm.nih.gov/38860566/
[Efron-23] Nonselective beta blockade enhances gut microbiome diversity in a rodent model of trauma, hemorrhage, and chronic stress.
Munley JA, Kelly LS, Park G, Pons EE, Apple CG, Kannan KB, Bible LE, Efron PA, Nagpal R, Mohr AM.
J Trauma Acute Care Surg. 2025 Feb 1;98(2):309-318. doi:10.1097/TA.0000000000004461. PMID: 39813154.
PubMed record for PMID: 39813154 — https://pubmed.ncbi.nlm.nih.gov/39813154/
[Efron-24] Home-based digital exercise training program to improve physical function of older sepsis survivors: protocol of the HEAL Sepsis randomized clinical trial.
Zeidan RS, Ohama MK, Evripidou N, Anton SD, Hamed LL, Lin Y, Leeuwenburgh C, Guirguis FW, Efron PA, Flynn S, Smith B, Bacher R, Baskaran N, Sarmiento Delgado J, Mankowski RT.
JMIR Res Protoc. 2024 Oct 17;13:e60270. doi:10.2196/60270. PMID: 39418096.
PubMed record for PMID: 39418096 — https://pubmed.ncbi.nlm.nih.gov/39418096/
[Efron-25] Multimodal nuclear factor-erythroid-2-related factor (NRF2) therapy in the context of mammalian target of rapamycin (mTOR) inhibition reprograms the acute systemic and pulmonary immune response after combined burn and inhalation injury.
Alves MD, Clark RA, Hernandez DA, Bucci MP, Chen D, Efron PA, Wallet SM, Keselowsky BG, Maile R.
Shock. 2024 Dec 1;62(6):772-782. doi:10.1097/SHK.0000000000002466. PMID: 39178221.
PubMed record for PMID: 39178221 — https://pubmed.ncbi.nlm.nih.gov/39178221/
[Efron-26] Corrigendum to “Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner” [NeuroImage 305 (2025) 120995].
Vo Q, Simon ZD, Park G, Nacionales DC, Gorski C, Barrios EL, Casadesus G, Efron PA, Moldawer LL, Nagpal R, Chakrabarty P, Febo M.
NeuroImage. 2025 Mar;308:121025. doi:10.1016/j.neuroimage.2025.121025. PMID: 39828487.
PubMed record for PMID: 39828487 — https://pubmed.ncbi.nlm.nih.gov/39828487/
[Efron-27] Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner.
Vo Q, Simon ZD, Park G, Nacionales DC, Gorski C, Barrios EL, Casadesus G, Efron PA, Moldawer LL, Nagpal R, Chakrabarty P, Febo M.
NeuroImage. 2025 Jan;305:120995. doi:10.1016/j.neuroimage.2024.120995. PMID: 39753162.
PubMed record for PMID: 39753162 — https://pubmed.ncbi.nlm.nih.gov/39753162/
Publications — Moldawer
Note: RM1 publications above that include Moldawer are not repeated here.
[Moldawer-1] The lipid intensive drug therapy for sepsis phase II pilot clinical trial.
Guirgis FW, Black LP, Henson M, Bertrand A, DeVos E, Ferreira J, Gao H, Wu SS, Leeuwenburgh C, Moldawer L, Moore F, Reddy ST.
Crit Care Med. 2024 Aug 1;52(8):1183-1193. doi:10.1097/CCM.0000000000006268. PMID: 38488429.
PubMed record for PMID: 38488429 — https://pubmed.ncbi.nlm.nih.gov/38488429/
[Moldawer-2] Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation.
Bellotti P, Ladd Z, Leroy V, Su G, Sharma S, Hartman JB, Krebs J, Viscardi C, Maile R, Moldawer LL, Efron PA, Sharma AK, Upchurch GR Jr.
FASEB J. 2024 Sep 30;38(18):e70067. doi:10.1096/fj.202400414RRR. PMID: 39320982.
PubMed record for PMID: 39320982 — https://pubmed.ncbi.nlm.nih.gov/39320982/
[Moldawer-3] Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.
Pickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NIA, Atkinson MA, Brakenridge S, Fung M, Messer W; IMPACC Network; Salehi-Rad R, Altman MC, Becker PM, Bosinger SE, Eckalbar W, Hoch A, Doni Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed EF, Langelier CR.
Nat Commun. 2025 Jan 10;16(1):586. doi:10.1038/s41467-025-55823-z. PMID: 39794319.
PubMed record for PMID: 39794319 — https://pubmed.ncbi.nlm.nih.gov/39794319/
Publications — Maile
Note: RM1 publications above that include Maile are not repeated here.
[Maile-1] Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair.
Chansoria P, Chaudhari A, Etter EL, Bonacquisti EE, Heavey MK, Le J, Maruthamuthu MK, Kussatz CC, Blackwell J, Jasiewicz NE, Sellers RS, Maile R, Wallet SM, Egan TM, Nguyen J.
Nat Commun. 2024 Jun 3;15(1):4720. doi:10.1038/s41467-024-48980-0. PMID: 38830847.
PubMed record for PMID: 38830847 — https://pubmed.ncbi.nlm.nih.gov/38830847/