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dedicated to finding New solutions for sepsis

The UF Sepsis and Critical Illness Research Center (SCIRC) is the first of its kind in the nation and studies long-term outcomes in patients treated for sepsis in the UF Health Shands Hospital’s surgical and trauma intensive care units. With a focus on innovation, collaboration, and academic excellence, the center aims to address some of the most pressing challenges facing society. We are a diverse team of researchers and scholars who work tirelessly to push the boundaries of knowledge and drive positive change. Our goals are to develop clinical solutions for sepsis, as well as illnesses that stem from it and their enduring effects.

 1) Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma.

Munley JA, Park G, Kelly LS, Kannan KB, Mankowski RT, Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Nagpal R, Efron PA.Ann Surg. 2024 Jun 12. doi: 10.1097/SLA.0000000000006385. Online ahead of print.PMID: 38864230

 2) Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot.

Unsinger J, Osborne D, Walton AH, Han E, Sheets L, Mazer MB, Remy KE, Griffith TS, Rao M, Badovinac VP, Brackenridge SC, Turnbull I, Efron PAMoldawer LL, Caldwell CC, Hotchkiss RS.Shock. 2024 May 3. doi: 10.1097/SHK.0000000000002377. Online ahead of print.PMID: 38754032

3) Transcriptomic Differences in Peripheral Monocyte Populations in Septic Patients Based on Outcome.

Barrios EL, Rincon JC, Willis M, Polcz VE, Leary J, Darden DB, Balch JA, Larson SD, Loftus TJ, Mohr AM, Wallet S, Brusko MA, Balzano-Nogueira L, Cai G, Sharma A, Upchurch GR Jr, Kladde MP, Mathews CE, Maile R, Moldawer LL, Bacher R, Efron PA.Shock. 2024 May 2. doi: 10.1097/SHK.0000000000002379. Online ahead of print.PMID: 38713581





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