dedicated to finding New solutions for sepsis

The UF Sepsis and Critical Illness Research Center (SCIRC) is the first of its kind in the nation and studies long-term outcomes in patients treated for sepsis in the UF Health Shands Hospital’s surgical and trauma intensive care units. With a focus on innovation, collaboration, and academic excellence, the center aims to address some of the most pressing challenges facing society. We are a team of researchers and scholars who work tirelessly to push the boundaries of knowledge and drive positive change. Our goals are to develop clinical solutions for sepsis, as well as illnesses that stem from it and their enduring effects.

learn about our ongoing projects

Listen to Our Podcast

Unveiling the Science Behind Sepsis

https://innovation.ufhealth.org/podcasts/?segitem=63094

Dr. Nicole Iovine and Dr. Philip Efron discuss Sepsis, including medical terminology, pathophysiology, risk factors, and its critical implications within the medical field.

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 See our newest publications:

Artificial Intelligence and Surgical Decision-making
Authors: Loftus TJ, Tighe PJ, Filiberto AC, Efron PA, Brakenridge SC, Mohr AM, Rashidi P, Upchurch GR Jr, Bihorac A.
Journal: JAMA Surg. 2020 Feb 1;155(2):148-158.
PMID: 31825465
🔗 https://pubmed.ncbi.nlm.nih.gov/31825465/

An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice
Authors: Park G, Kadyan S, Hochuli N, Salazar G, Laitano O, Chakrabarty P, Efron PA, Zafar MA, Wilber A, Nagpal R.
Published: September 10, 2024.
PMID: 39255397
🔗 https://pubmed.ncbi.nlm.nih.gov/39255397/

Proteomic Profiling of Hindlimb Skeletal Muscle Disuse in a Murine Model of Sepsis
Authors: Boeno FP, Roesch LFW, Efron PA, Laitano O.
Journal: Critical Care Explorations. August 2024.
PMID: 39162648
🔗 https://journals.lww.com/ccejournal/fulltext/2024/08000/proteomic_profiling_of_hindlimb_skeletal_muscle.14.aspx#

Development and Optimization of a Diluted Whole Blood ELISpot Assay to Test Immune Function
Authors: Ungaro RF, Xu J, Kucaba TA, Rao M, Bergmann CB, Brakenridge SC, Efron PA, Goodman MD, Gould RW, Hotchkiss RS, Liang M, Mazer MB, McGonagill PW, Moldawer LL, Remy KE, Turnbull IR, Caldwell CC, Badovinac VP, Griffith TS.
Journal: Journal of Immunological Methods. Available online: August 13, 2024.
PMID: 39147231
🔗 https://www.sciencedirect.com/science/article/pii/S0022175924001285

Severe Trauma Leads to Sustained Muscle Loss, Induced Frailty, and Distinct Temporal Changes in Myokine and Chemokine Profiles of Older Patients
Authors: Polcz VE, Barrios EL, Cox MC, Rocha I, Liang M, Hawkins RB, Darden D, Ungaro R, Dirain M, Mankowski R, Mohr AM, Moore FA, Moldawer LL, Efron PA, Brakenridge SC, Loftus TJ.
Journal: Surgery. 2024 Jul;176(1):45-55.
PMID: 39179433
🔗 https://pubmed.ncbi.nlm.nih.gov/39179433/

Multimodal Nuclear Factor-Erythroid-2-Related Factor (NRF2) Therapy in the Context of Mammalian Target of Rapamycin (mTOR) Inhibition Reprograms the Acute Systemic and Pulmonary Immune Response After Combined Burn and Inhalation Injury
Authors: Alves MD, Clark RA, Hernandez DA, Bucci MP, Chen D, Efron PA, Wallet SM, Keselowsky BG, Maile R.
Published: 2024.
PMID: 39178221
🔗 https://pubmed.ncbi.nlm.nih.gov/39178221/

Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot
Authors: Unsinger J, Osborne D, Walton AH, Han E, Sheets L, Mazer MB, Remy KE, Griffith TS, Rao M, Badovinac VP, Brackenridge SC, Turnbull I, Efron PA, Moldawer LL, Caldwell CC, Hotchkiss RS.
Journal: Shock. 2024 May 3.
PMID: 38754032
🔗 https://pubmed.ncbi.nlm.nih.gov/38754032/

Transcriptomic Differences in Peripheral Monocyte Populations in Septic Patients Based on Outcome
Authors: Barrios EL, Rincon JC, Willis M, Polcz VE, Leary J, Darden DB, Balch JA, Larson SD, Loftus TJ, Mohr AM, Wallet S, Brusko MA, Balzano-Nogueira L, Cai G, Sharma A, Upchurch GR Jr, Kladde MP, Mathews CE, Maile R, Moldawer LL, Bacher R, Efron PA.
Journal: Shock. 2024 May 2.
PMID: 38713581
🔗 https://pubmed.ncbi.nlm.nih.gov/38713581/